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Pack Size : 96 Well
Package Kit Components :
Usage : The New Life cTnl Elisa is intended for the quantities determination of cardiac Troponin I in human serum. Measurements of Troponin I values are useful in the evaluation of acute myocardial infaraction (AMI)
Description : Troponin is the inhibitory or contractile regulating protein complex of striated muscle. it is located periodically along the thin filament of the muscle and consists of three distinct proteins: Troponin I, Troponin C, and Troponin I. Likewise the Triponin I subunit exists in three separate isoforms : two in fast-twitch and slow-twitch skeletal muscle fiber and one in cardiac muscle .The cardiac isoform (cTnl)is about 40% dissimilar, has a molecular weight of 22,500 Daltons, cardiac Troponin I (cTnl)has been useful in the differential diagnosis of patients presenting to Emergency department (ED) with chest pain 18-20. Myocardial infarction is diagnosed when blood levels of sensitive and specific biomarkers, such as cardiac Troponin, The MB isoenzyme of creatine kinase (CK-MB), and myoglobin,are increased in a clinical setting of acute ischemia. The most recently described and preferred biomarker for myocardial damage is cardiac Troponin (I or T) . The Cardiac Troponin exhibit myocardial tissue specificity and high sensitivity. The level of cTnl remains elevated for a much longer period of time (6-10 days ), thus providing for a longer window of detection of cardiac injury , normal level of cTnl in the blood are very low. After the onset of an AMI ,cTnl Levels increase substantially and are measurable in serum within 4 to 6 hours, with peak concentrations reached in aprox 12 to 24 hours after infarction . The cTnl Enzyme Immunoassay provides a rapid ,sensitive. And reliable assay for the quantitative measurement of cardiac-specific Troponin I. The antibodies developed for the test will determine a minimal concentration of 1.0 ng/ml, and theres no cross-reactivity with human cardiac of skeletal Troponin T or I.
