Pack Size : 96 Well

Package Kit Components :

• Microwells coated
• CEA Standard
• CEA Enzyme Conjugate
• TMB Reagent
• Stop Solution
• Wash concentrate
• Technical Insert

Usage : The New Life CEA ELISA Kit is intended for the quantitative measurement of CEA in human serum.

Description : Carcinoembryonic antigen (CEA), a 180 kD intercellular adhesion molecule expressed in high concentrations in the fetus but normally not found in adult serum because the synthesis of this protein ceases after birth. However reappear in a high concentration in the sera of patients with colorectal (57%), gastric (41%), hepatocellular (45%), pancreatic (59%) and biliary (59%) carcinoma. The serum concentration of CEA can also be elevated in benign diseases of the colorectum (inflammatory bowel disease 17%), stomach (chronic gastritis and peptic ulcer 14%), liver (cirrhosis and hepatitis 17%) and pancreas (21%). Elevated levels of CEA have also been observed in patients with inflammatory nonmalignant diseases like pulmonary emphysema, alcoholic cirrhosis, and pancreatitis and in heavy smokers. In contrast to cancer these elevations are transitory. The serum levels drop back into the normal range within a few weeks. The primary use of CEA is to monitor patients after surgery for recurrent colorectal carcinoma. Serum CEA has sensitivity between 60% and 95% in detecting recurrences prior to clinical detection and a lead-time between 2 and 10 months (positive predictive value 65%; negative predictive value 70%). False- positive results are usually below 10.0 ng/ml.