Pack Size : 96 Well
Package Kit Components :
Usage : Immunoenzymetric assay for the in vitro quantitative measurment of 25-hydroxyvitamin D2 and D3 (25OH-D2 and 25OH-D3) in serum
Description : Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis. Vitamin D deficiency can result from inadequate intake coupled with inadequate sunlight exposure, disorders that limit its absorption, conditions that impair conversion of vitamin D into active metabolites, such as liver or kidney disorders. Deficiency results in impaired bone mineralization, and leads to bone softening diseases, rickets in children and osteomalacia in adults, and possibly contributes to osteoporosis. In the liver, the vitamin is hydroxylated to 25-hydroxyvitamin D (25-OH Vitamin D), the major circulating metabolite of Vitamin D. Although 1,25-(OH)2 Vitamin D portrays the biological active form of Vitamin D, which is synthesized in the kidney, it is widely accepted that the measurement of circulating 25-OH Vitamin D provides better information with respect to patients Vitamin D status . Clinical applications of 25-OH Vitamin D measurements are the diagnosis and therapy control of postmenopausal osteoporosis, rickets, osteomalacia, renal osteodystrophy, pregnancy, neonatal hypocalcemia and hyperparathyroidism.